Purified Anti-Human CD47 Antibody [CC2C6D4] - E-AB-F1060A

Purified Anti-Human CD47 Antibody [CC2C6D4]

Size: 100μg

Catalogue Number: E-AB-F1060A-100

Citations, Manuals and MSDS Available upon request.

Abbreviation: CD47

Target Synonym: Leukocyte surface antigen CD47, Cd47, Integrin-associated protein, IAP,

Conjugation: Unconjugated

Host: Mouse

Species Reactivity: Human

Application: FCM

Usage: Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per 10^6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Isotype: Mouse IgG1, κ

Clone No.: CC2C6D4

UNIProt ID: Q08722

Background: CD47 also known as Rh-associated protein, gp42, integrin-associated protein (IAP), and neurophilin, is a 42-52 kD member of the immunoglobulin superfamily containing a five-pass transmembrane attachment. Two splice variants have been described in the cytoplasmic tail, the shorter form is expressed in bone-marrow-derived cells, endothelial cells, and fibroblasts while the longer form is expressed by neural tissues. CD47 expression is widely distributed in hematopoietic cells including thymocytes, T cells, B cells, monocytes, platelets, and erythrocytes as well as epithelial cells, endothelial cells, fibroblasts, and neural tissues. CD47 functions as an adhesion molecule and thrombospondin receptor and is non-covalently associated with β3 integrins CD51/CD61, CD41/CD61. Thrombospondin is a ligand for CD47, in the absence of CD47 mice show defects in host defense and β3 integrin-dependent ligand binding, migration, and cellular activation. CD47 is also part of the Rh complex on erythrocytes.

Concentration: 0.5 mg/mL

Control Catalogue Number: E-AB-F09793A

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.

GeneID: 961

Storage: This product can be stored at 2-8°C for 12 months. Do not freeze.

Shipping: Ice bag