Recombinant APC Monoclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: E-AB-81529-50, E-AB-81529-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: APC
Target Synonym: Adenomatous Polyposis Coli; Adenomatous polyposis coli protein; Apc; APC; CC1; Deleted in polyposis 2.5; DP2; DP2.5; DP3; FAP; FPC; GS; Protein APC
Research Areas: Cancer, Cell Biology, Cardiovascular, Epigenetics and Nuclear Signaling, Neuroscience, Stem Cells
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human
Application: WB
Isotype: IgG
Clonality: Rabbit Monoclonal
Clone No.: R06-2E4
UNIProt ID: P25054
Background: This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
Concentration: 300 μg/mL
Immunogen: A synthetic peptide of human APC
Buffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Purification Method: Affinity Purified
Dilution: WB 1:500-1:1000
Calculated MW: 312kDa
Observed MW: 160kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only