Recombinant CDC42 Monoclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: E-AB-81545-50, E-AB-81545-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: CDC42
Target Synonym: CDC42; CDC42Hs; G25K; TKS
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal Transduction
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Rat
Application: WB
Isotype: IgG
Clonality: Rabbit Monoclonal
Clone No.: R01-1C7
UNIProt ID: P60953
Background: The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.
Concentration: 300 μg/mL
Immunogen: Recombinant protein of human CDC42
Buffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Purification Method: Affinity Purified
Dilution: WB 1:1000-1:2000
Calculated MW: 21kDa
Observed MW: 21kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only