Recombinant Cynomolgus LAG-3/CD223 Protein (Fc Tag)
Sizes: 10μg, 50μg
Catalogue Numbers: PKSQ050015-10, PKSQ050015-50
Citations, Manuals and MSDS Available upon request.
Abbreviation: LAG-3; CD223
Target Synonym: Lymphocyte activation gene 3 protein; LAG3; LAG-3; Protein FDC; CD223
Target Species: Cynomolgus macaques
Expression Host: HEK293 Cells
Fusion Tag: C-Fc
Accession: XP_005570011.1
Background: Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.
Sequence: Ala18-His449(Pro74)
Purity: > 90 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from a 0.2 μm filtered solution ofPBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 73.6 kDa
Observed MW: 90 kDa
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Research Use Only