Recombinant EGFR Monoclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: E-AB-81439-50, E-AB-81439-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: EGFR
Target Synonym: Cell growth inhibiting protein 40; Cell proliferation inducing protein 61; EGF R; EGFR; Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog); Epidermal growth factor receptor; erb-b2 receptor tyrosine kinase 1; ERBB; ERBB1; Errp; HER1; mENA;
NISBD2; SA7; wa2; Wa5
Research Areas: Cancer, Signal Transduction
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Mouse
Application: WB, IF
Isotype: IgG
Clonality: Rabbit Monoclonal
Clone No.: R03-6B1
UNIProt ID: P00533
Background: EGFR, also named as ERBB1, is a cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. The gene resides on chromosome 7p12, encoding a 170 kDa membrane-associated glycoprotein. Recent studies have shown EGFR plays a critical role in cancer development and progression, including cell proliferation, apoptosis, angiogenesis, and metastatic spread. Mutations in this gene are associated with lung cancer.
Concentration: 300 μg/mL
Immunogen: A synthetic peptide of human EGFR
Buffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Purification Method: Affinity Purified
Dilution: WB 1:1000-1:2000 IF 1:50-1:200
Calculated MW: 134kDa
Observed MW: 175kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only