Recombinant Human Arginase-1 Protein (His Tag)
Size: 100μg
Catalogue Numbers: PDEH100053-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: Arginase-1
Target Synonym: ARG1; Al; Arginase 1; Arginase liver;
UNIProt ID: P05089
Research Areas: Signal Transduction; metabolism;
Target Species: Human
Expression Host: E.coli
Fusion Tag: N-His
Accession: P05089
Background: Arginase 1, also known as liver arginase, is a binuclear manganese metalloenzyme. It is a key enzyme of the urea cycle that catalyses the conversion of L-arginine into L-ornithine and urea, the final cytosolic reaction of urea formation in the mammalian liver. Arginase 1 is abundantly expressed in liver, but it is also expressed in cells and tissues that lack a complete urea cycle, including lung.-Arginase is a critical regulator of nitric oxide synthesis and vascular function. It is implicated in a variety of human diseases including vascular disease, pulmonary disease, infectious disease, immune cell function and cancer. In humans, hereditary defects in arginase result in an accumulation of arginine in the blood known as hyperarginemia. Arginase deficiency can also result in the accumulation of nitrogen in the form of ammonia, which results in hyperammonemia.
Sequence: Met1-Lys322
Purity: > 90 % as determined by reducing SDS-PAGE.
Formulation: Supplied as sterile solution of 25mM Tris-HCl, 150mM KCl, 1mM DTT, 20% glycerol, pH 8.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Not Applicable
Endotoxin: Please contact us for more information.
Calculated MW: 36.9 kDa
Observed MW: 38-40 kDa
Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Research Use Only