Recombinant Human BLK Protein (His Tag)
Sizes: 10μg, 50μg
Catalogue Numbers: PKSH032011-10, PKSH032011-50
Citations, Manuals and MSDS Available upon request.
Abbreviation: BLK
Target Synonym: Tyrosine-Protein Kinase Blk; B Lymphocyte Kinase; p55-Blk; BLK; MODY11
Research Areas: Cell biology
Target Species: Human
Expression Host: E.coli
Fusion Tag: C-6His
Accession: NP_001706.2
Background: Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain. BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulines and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Defects in BLK are a cause of maturity-onset diabetes of the young type 11 (MODY11).
Sequence: Gly2-Pro505
Purity: > 85 % as determined by reducing SDS-PAGE.
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris, 500mM NaCl, 1mM DTT, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Not Applicable
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 58.7 kDa
Observed MW: 58.7 kDa
Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Research Use Only