Recombinant Human CD155/PVR/NECL5 Protein (His Tag)(Active)
Sizes: 10μg, 50μg
Catalogue Numbers: PKSH033563-10, PKSH033563-50
Citations, Manuals and MSDS Available upon request.
Abbreviation: CD155; PVR; NECL5
Target Symptom: Poliovirus Receptor; Nectin-Like Protein 5; NECL-5; CD155; PVR; PVS
Research Area: Microbiology
Target Species: Human
Expression Host: HEK293 Cells
Application: ELISA
Fusion Tag: C-His
UNIProt ID: P15151
Accession: P15151
Background: Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV); an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains; a transmembrane segment; and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the PVR mRNA yields four different isoforms (α; β; γ; and δ) with identical extracellular domains.
Activity: Immobilized Human TIGIT-Fc(Cat: PKSH033510) at 5μg/ml(100 μl/well) can bind Human PVR-His. The ED50 of Human PVR-His is 11.66 ug/ml.
Sequence: Trp21-Asn343(Ile340Met)
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Not Applicable
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 36.13 kDa
Observed MW: 58 kDa
Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Research Use Only