Recombinant Human CXCR4 (C28A) Protein (His Tag)
Size: 100μg
Catalogue Numbers: PDEH100054-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: CXCR4
Target Synonym: C-X-C chemokine receptor type 4; CD184; FB22; Fusin; HM89; HSY3RR; LAP3; LCR1; NPYR; SDF 1 receptor; WHIM
UNIProt ID: P61073
Research Areas: Microbiology; Neuroscience; Cancer; immunology; metabolism; Stem cells
Target Species: Human
Expression Host: E.coli
Fusion Tag: N-GST
Accession: P61073
Background: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ions levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhance intracellular calcium ions and reduce cellular cAMP levels. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.
Sequence: Met1-Lys38
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: Please contact us for more information.
Calculated MW: 31.2 kDa
Observed MW: 32-35 kDa
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Research Use Only