Recombinant Human GLUT6/SLC2A6 protein (GST,His tag)
Size: 100μg
Catalogue Numbers: PDEH100310-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: GLUT6; SLC2A6
Target Synonym: Solute carrier family 2; facilitated glucose transporter member 6; SLC2A6; Glucose transporter type 6; GLUT6
UNIProt ID: Q9UGQ3
Research Areas: Metabolism; Signal Transduction
Target Species: Human
Expression Host: E.coli
Fusion Tag: N-GST & C-His
Accession: Q9UGQ3-1
Background: GLUT6 as a functionally uncharacterized transporter that putatively works in inflammatory responses. Inflammatory stimuli increase GLUT6 expression level, although GLUT6-knockout mice exhibit a subtle phenotype to lipopolysaccharide administration. Metabolomics and in vitro analyses show that GLUT6 functions as a glycolysis modulator in inflammatory macrophages. GLUT6 does not mediate glucose uptake and is localized on lysosomal membranes. We conclude that GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates inflammatory responses by affecting the metabolic shift in macrophages.
Sequence: Asn 216-Thr 289
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: Please contact us for more information.
Calculated MW: 33.03 kDa
Observed MW: 35 kDa
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Research Use Only