Recombinant Human Kallikrein 1/KLK1 Protein (His Tag)
Sizes: 10μg, 50μg
Catalogue Numbers: PKSH032664-10, PKSH032664-50
Citations, Manuals and MSDS Available upon request.
Abbreviation: Kallikrein 1; KLK1
Target Synonym: Kallikrein-1; Kidney/Pancreas/Salivary Gland Kallikrein; Tissue Kallikrein; KLK1
UNIProt ID: P06870
Research Areas: Signal Transduction; Cell biology; Cardiovascular; Cancer;
Target Species: Human
Expression Host: HEK293 Cells
Fusion Tag: C-6His
Accession: P06870
Background: Kallikrein-1 (KLK1) is a member of human tissue Kallikrein family. Human KLK1 precursor contains a singal peptide (residues 1 to 18), a short pro peptide (residues 19 to 24) and a mature chain (residues 25 to 262). The function of KLK1 is to cleave Kininogen in order to release the vasoactive Kinin peptide (Lysyl-Bradykinin or Bradykinin). The Kinin peptide controls blood pressure reduction, vasodilation, smooth muscle relaxation and contraction, pain induction and inflammation. KLK1 also plays a role in angiogensis and tumorigenesis.
Sequence: Pro19-Ser262
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 2mM CaCl2, pH 8.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Not Applicable
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 28.2 kDa
Observed MW: 38 kDa
Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Research Use Only