Recombinant Human/Mouse/Rat GDF-8/Myostatin
Sizes: 10μg, 50μg
Catalogue Numbers: PKSR030542-10, PKSR030542-50
Citations, Manuals and MSDS Available upon request.
Abbreviation: GDF-8; Myostatin
Target Symptom: Growth/differentiation factor 8; GDF-8; Myostatin; Mstn; Gdf8
Research Area: Signal Transduction; Cell biology; Neuroscience; Cancer;
Target Species: Human/Mouse/Rat
Expression Host: HEK293 Cells
Fusion Tag: None
UNIProt ID: O14793
Accession: O14793
Background: Growth/differentiation factor 8(Mstn, GDF-8) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. It is expressed specifically in developing and adult skeletal muscle. It exists as a homodimer, and interacts with WFIKKN2, leading to inhibit its activity. This protein can act specifically as a negative regulator of skeletal muscle growth. It regulates cell growth and differentiation in both embryonic and adult tissues.
Sequence: Lys262-Ser375
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 13.1 kDa
Observed MW: 12-15 kDa
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Research Use Only