Recombinant Human SDHA protein (His tag)
Size: 100μg
Catalogue Numbers: PDEH100333-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: SDHA
Target Synonym: Succinate dehydrogenase [ubiquinone] flavoprotein subunit; mitochondrial;
SDHA; Flavoprotein subunit of complex II (Fp); SDHF; SDH2
UNIProt ID: P31040
Research Areas: Cancer; Cell Biology; Metabolism; signal Transduction; Tag and Cell Markers
Target Species: Human
Expression Host: E.coli
Fusion Tag: N-His & C-His
Accession: P31040
Background: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone.Defects in SDHA are a cause of mitochondrial complex II deficiency (MT-C2D). A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations. Clinical features include psychomotor regression in infants, poor growth with lack of speech development, severe spastic quadriplegia, dystonia, progressive leukoencephalopathy, muscle weakness, exercise intolerance, cardiomyopathy. Some patients manifest Leigh syndrome or Kearns-Sayre syndrome.
Sequence: Ala 43-Tyr 664
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: Please contact us for more information.
Calculated MW: 68.31 kDa
Observed MW: 70 kDa
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Research Use Only