Recombinant Human SOCS2 protein (His tag)
Size: 100μg
Catalogue Numbers: PDEH100325-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: SOCS2
Target Synonym: Suppressor of cytokine signaling 2; SOCS2; Cytokine-inducible SH2 protein 2; STAT-induced STAT inhibitor 2
UNIProt ID: O14508
Research Areas: Immunology; Neuroscience; Signal Transduction
Target Species: Human
Expression Host: E.coli
Fusion Tag: N-His & C-His
Accession: O14508
Background: SOCS-2 (Suppressor of cytokine signaling 2; also CIS-2 and SSI-2) is a 25 kDa member of the SOCS family of proteins. It is an SH2-domain containing cytoplasmic adaptor protein expressed by multiple cell types. It blocks receptor signaling by binding to phosphorylated tyrosines in the cytoplasmic domain of select receptors, including the receptors for leptin, IGF-I and GH. Human SOCS-2 is 198 amino acids (aa) in length and contains one SH2 domain (aa 48-156) and a SOCS box (aa 160-198) that mediates interaction with elongin B or C of the E3 ubiquitin ligase complex. There is one splice variant that shows an Arg-rich eight aa substitution for aa 31-39. Full-length SOCS-2 is 94% and 96% aa identical to mouse and porcine SOCS-2, respectively.
Sequence: Met 1-Val 198
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: Please contact us for more information.
Calculated MW: 21.67 kDa
Observed MW: 25 kDa
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Research Use Only