Recombinant Human SOD2/Mn-SOD Protein (His Tag)
Sizes: 10μg, 50μg
Catalogue Numbers: PKSH033072-10, PKSH033072-50
Citations, Manuals and MSDS Available upon request.
Abbreviation: SOD2; Mn-SOD
Target Synonym: Superoxide Dismutase [Mn] Mitochondrial; SOD2
UNIProt ID: P04179
Research Areas: Signal Transduction; Cell biology; Cardiovascular; Neuroscience; Cancer; metabolism;
Target Species: Human
Expression Host: E.coli
Fusion Tag: N-6His
Accession: P04179
Background: Superoxide Dismutase (SOD2) is a number of the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. The SOD2 protein transforms toxic superoxide and a byproduct of the mitochondrial electron transport chain into hydrogen peroxide and diatomic oxygen. Genetic variation in SOD2 is associated with microvascular complications of diabetes type 6 (MVCD6); idiopathic cardiomyopathy (IDC); sporadic motor neuron disease; and cancer. SOD2 destroys superoxide anion radicals which are usually produced within the cells and which are toxic to biological systems.
Sequence: Lys25-Lys222
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris, 100mM NaCl, 50% glycerol, pH 8.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Not Applicable
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 23.7 kDa
Observed MW: 23 kDa
Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Research Use Only