Recombinant Human TPP1/CLN2 Protein (His Tag)
Sizes: 10μg, 50μg
Catalogue Numbers: PKSH033493-10, PKSH033493-50
Citations, Manuals and MSDS Available upon request.
Abbreviation: TPP1; CLN2
Target Symptom: Tripeptidyl-Peptidase 1; TPP-1; Cell Growth-Inhibiting Gene 1 Protein; Lysosomal Pepstatin-Insensitive Protease; LPIC; Tripeptidyl Aminopeptidase; TPP1; CLN2; GIG1; LPIC; SCAR7; TPP-1
Research Area: Cell biology; Neuroscience
Target Species: Human
Expression Host: HEK293 Cells
Fusion Tag: C-His
UNIProt ID: O14773
Accession: O14773
Background: Tripeptidyl-Peptidase 1 (TPP1) belongs to the peptidase S53 family. TPP1 is detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues. TPP1 is lysosomal serine protease with tripeptidyl-peptidase I activity. TPP1 may act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. TPP1 requires substrates with an unsubstituted N-terminus. TPP1 mutations have also been shown to cause neuronal ceroid lipofuscinosis type 2 (CLN2).
Sequence: Ser20-Pro563
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM GaCl2, 10%Glycerol, pH7.5.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Not Applicable
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 60.35 kDa
Observed MW: 74 kDa
Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Research Use Only