Recombinant Human UROS/UROIIIS Protein (His Tag)
Sizes: 10μg, 50μg
Catalogue Numbers: PKSH033200-10, PKSH033200-50
Citations, Manuals and MSDS Available upon request.
Abbreviation: UROS; UROIIIS
Target Symptom: Uroporphyrinogen-III Synthase; UROIIIS; UROS; Hydroxymethylbilane Hydrolyase [Cyclizing]; Uroporphyrinogen-III Cosynthase; UROS
Research Area: Cell biology
Target Species: Human
Expression Host: E.coli
Fusion Tag: C-6His
UNIProt ID: P10746
Accession: P10746
Background: Uroporphyrinogen-III Synthase is an enzyme which belongs to the uroporphyrinogen-III synthase family. Uroporphyrinogen-III Synthase is ubiquitous and it is involved in Porphyrin metabolism. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as Methionine synthesis (Vitamin B12) or oxygen transport (Heme). Uroporphyrinogen-III Synthase can catalyze cyclization of the linear Tetrapyrrole, Hydroxymethylbilane, to the Macrocyclic Uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of Porphyrins. Defects in Uroporphyrinogen-III Synthase are the cause of Congenital Erythropoietic Porphyria (CEP).
Sequence: Met 1-Cys265
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 10% Glycerol, pH 8.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Not Applicable
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 29.7 kDa
Observed MW: 29 kDa
Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Research Use Only