Recombinant Mouse Serpin A3N Protein (His Tag)
Sizes: 10μg, 50μg
Catalogue Numbers: PKSM041279-10, PKSM041279-50
Citations, Manuals and MSDS Available upon request.
Abbreviation: Serpin A3N
Target Synonym: Serine protease inhibitor A3N; Serpin A3N; Serpina3n; Spi2
UNIProt ID: Q91WP6
Target Species: Mouse
Expression Host: HEK293 Cells
Fusion Tag: C-His
Accession: Q91WP6
Background: Serine protease inhibitor A3N(Serpin A3N) is a serine protease inhibitor that is structurally related to α1 antichymotrypsin encoded by the SERPINA3 gene. Serpin A3N is highly expressed in brain, testis, lung, thymus, and spleen. It is expressed with low levels in bone marrow, kidney and skeletal muscle. Serpin A3N secreted by Sertoli cells may regulate the activity of locally produced Granzyme B. Granzyme B inhibition by Serpin A3N may therefore regulate Granzyme Bmediated killing by cytotoxic lymphocytes, providing a means to disable cellmediated immune responses.
Sequence: Phe21-Lys418
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris, 150mM NaCl, pH8.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Not Applicable
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 45.6 kDa
Observed MW: 58 kDa
Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Research Use Only