Recombinant Rat Interleukin-12 subunit beta/IL-12B protein (His tag)
Sizes: 20μg, 100μg
Catalogue Numbers: PDMR100029-20, PDMR100029-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: IL-12B
Target Synonym: Interleukin-12 subunit beta; Cytotoxic lymphocyte maturation factor 40 kDa subunit; IL-12 subunit p40; Il12b; rCG_35081
UNIProt ID: E9PU71
Research Areas: Signal Transduction; epigenetics and nuclear signal; immunology;
Target Species: Rat
Expression Host: HEK293 Cells
Fusion Tag: C-His
Accession: E9PU71
Background: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
Sequence: Met1-Ser335
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: Please contact us for more information.
Calculated MW: 36.74 kDa
Observed MW: 42 kDa
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Research Use Only