Recombinant Rat TGFBR1 protein (His tag)
Size: 100μg
Catalogue Numbers: PDER100074-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: TGFBR1
Target Synonym: AAT5; Activin receptor like kinase 5; ACVRLK4; ALK-5; LDS1A; LDS2A; MSSE; SKR4; TbetaR I; TGF-beta receptor type-1; TGFBR1; Transforming growth factor beta receptor 1
UNIProt ID: P80204
Research Areas: Cardiovascular; Signal Transduction; Stem Cells; Cancer; Metabolism; Neuroscience
Target Species: Rat
Expression Host: E.coli
Fusion Tag: N-His
Accession: P80204
Background: Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70-85 kDa), and Type III (250-350 kDa). The Type III receptor, a proteoglycan that exists in membrane-bound and soluble forms, binds TGF-beta 1, TGF-beta 2, and TGF-beta 3 but does not appear to be involved in signal transduction. The Type II receptor is a membrane-bound serine/threonine kinase that binds TGF-beta 1 and TGF-beta 3 with high affinity and TGF-beta 2 with a much lower affinity. The Type I receptor, originally known as ALK-5 (Activin receptor-like kinase) is also a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. Current evidence suggests that signal transduction requires the cytoplasmic domains of both the Type I and Type II receptors.
Sequence: Leu 311-Met 501
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: Please contact us for more information.
Calculated MW: 20.9 kDa
Observed MW: 28 kDa
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Research Use Only