Recombinant Wnt5a Monoclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: E-AB-81621-50, E-AB-81621-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: Wnt5a
Target Synonym: hWNT5A; Wnt5a; WNT5A
Research Areas: Cancer, Neuroscience, Stem Cells
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human
Application: WB, IF
Isotype: IgG
Clonality: Rabbit Monoclonal
Clone No.: R08-4A3
UNIProt ID: P41221
Background: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants.WNT5A (Wnt Family Member 5A) is a Protein Coding gene. Diseases associated with WNT5A include Robinow Syndrome, Autosomal Dominant 1 and Autosomal Dominant Robinow Syndrome. Among its related pathways are Validated targets of C-MYC transcriptional repression and Wnt Signaling Pathways: beta-Catenin-independent Wnt/Ca2+ Signaling and Other Non-canonical Wnt Signaling Pathways. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein domain specific binding. An important paralog of this gene is WNT5B.
Concentration: 300 μg/mL
Immunogen: A synthetic peptide of human Wnt5a
Buffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Purification Method: Affinity Purified
Dilution: WB 1:500-1:1000 IF 1:50-1:100
Calculated MW: 42kDa
Observed MW: 45kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only