ROCK1 Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-70124-60, E-AB-70124-120, E-AB-70124-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: ROCK1
Target Synonym: coiled-coil-containing protein kinase 1; coiled-coil-containing protein kinase I; MGC131603; MGC43611; p160 Rhoassociated coiled coil-forming protein kinase; p160 ROCK-1; p160 ROCK1; p160ROCK; PRO0435; Renal carcinoma antigen NY REN 35; Renal carcinoma antigen NY-REN-35; Rho associated coiled coil containing protein kinase 1; Rho associated protein kinase 1; Rho kinase; Rho-alpha kinase; Rho-associated; Rho-associated protein kinase 1; ROCK I; ROCK-I; ROCK1; ROCK1; Rok; rokalpha
Research Areas: Cancer, Cell Biology, Signal Transduction
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Mouse, Rat
Application: IHC
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: P70335,Q63644
Background: This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
Concentration: 300 μg/mL
Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse Rock1
Buffer: PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Purification Method: Affinity purification
Dilution: IHC 1:100-1:400
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only