SARS-CoV-2 NSP3 Polyclonal Antibody (2019-nCoV)
Sizes: 50μL, 100μL
Catalogue Numbers: E-AB-V1039-50, E-AB-V1039-100
Citations, Manuals and MSDS Available upon request.
Target Synonym: Non-structural protein 3; PL2-PRO; Papain-like proteinase; PL-PRO; Replicase polyprotein 1a
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: SARS-COV2
Application: ELISA
Isotype: IgG
Clonality: Polyclonal
Background: Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3. Prevents also host NF-kappa-B signaling.
Concentration: 0.33mg/ml
Immunogen: Recombinant SARS-CoV-2 NSP3
Buffer: PBS, pH7.4, containing 0.05% proclin300, 50% glycerol.
Dilution: ELISA:1:4000~1:8000
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only