SDHB Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-63462-60, E-AB-63462-120, E-AB-63462-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: SDHB
Target Synonym: SDHB; CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP
Research Areas: Cancer,Cell biology,Metabolism,Signal transduction
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Application: WB, IF
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: P21912
Background: Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.
Concentration: 1 mg/mL
Immunogen: Recombinant fusion protein of human SDHB
Buffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.
Purification Method: Affinity purification
Dilution: WB 1:500-1:2000, IF 1:50-1:200
Calculated MW: 31kDa
Observed MW: 32KDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only