SEMA4A Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-15382-60, E-AB-15382-120, E-AB-15382-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: SEMA4A
Target Synonym: CORD10; RP11 54H19 2; RP35; SEM4A; Sema B; Sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain 4A; Sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain semaphorin 4A; Sema domain; immunoglobulin domain (Ig); transmembrane domain (TM) and short cytoplasmic domain; (semaphorin); Sema4a; SEMAB; Semaphorin 4A precursor; Semaphorin B; Semaphorin-4A; Semaphorin-B; SEMB
Research Areas: Cancer, Cardiovascular, Neuroscience
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human
Application: IHC, ELISA
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: Q9H3S1
Background: This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Concentration: 0.8 mg/mL
Immunogen: Recombinant protein of human SEMA4A
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method: Affinity purification
Dilution: IHC 1:30-1:150
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only