APC Anti-Mouse CD115/CSF-1R Antibody (AFS98)
Sizes: 25μg, 100μg
Catalogue Numbers: APC-30157U-25, APC-30157U-100
Citations, Manuals and MSDS Available upon request.
Target: Mouse CD115/CSF-1R
Form: Liquid
Conjugation: APC
Conjugation Information: APC is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 660 nm (e.g., a 660/20 nm bandpass filter).
Host: Rat
Clonality: Monoclonal
Clone ID: AFS98
Isotype: IgG2a, κ
Storage: PBS with 0. 1% sodium azide, 1%BSA, pH 7.3, 2-8℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.
Synonyms: CD115| CSF-1 receptor (EC:2.7.10.1)| CSF-1-R| CSF-1R| Csf1r| Csfmr| Fms| M-CSF-R| Macrophage colony-stimulating factor 1 receptor| Proto-oncogene c-Fms
Uniprot ID: P09581
Reactivity: Mouse
Tested Application: FC
Recommended Dilution: Each lot of this antibody is quality control tested by Flow cytometryometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1μg/10⁶ cells in 100 μL volume].
Gene ID: 12978
Category: Flow cytometryometry Antibodies
Research Use Only