Biotin Anti-Mouse IL-17A Antibody (TC11-18H10.1)
Sizes: 25μg, 100μg
Catalogue Numbers: Biotin-30098U-25, Biotin-30098U-100
Citations, Manuals and MSDS Available upon request.
Target: Mouse IL-17A
Form: Liquid
Conjugation: Biotin
Host: Rat
Clonality: Monoclonal
Clone ID: TC11-18H10.1
Isotype: IgG1, κ
Storage: PBS with 0. 1% sodium azide, 1%BSA, pH 7.3, 2-8℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with Monoclonal Antibody is able to ameliorate the disease course.
Synonyms: CTLA-8| CTLA8| Cytotoxic T-lymphocyte-associated antigen 8| IL-17| IL-17A| Interleukin-17A
Uniprot ID: Q62386
Reactivity: Mouse
Tested Application: FC
Recommended Dilution: Each lot of this antibody is quality control tested by Flow cytometryometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1μg/10⁶ cells in 100 μL volume].
Gene ID: 16171
Category: Flow cytometryometry Antibodies
Research Use Only