Mouse Monoclonal Antibody to Human CDNF
Size: 100 µg
Catalogue Number: 301-100
Citations, Manuals and MSDS Available upon request.
Immunogen: Human CDNF
Immunogen Description: Recombinant human CDNF protein produced using CHO-based Icosagen Cell factory Ltd. proprietary suspension cell line. Purified from cell culture supernatant
Background: CDNF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- (Lindholm et al. 20007; Voutilainen et al., 2011) and MPTP-induced degeneration (Airavaara et al., 2012) of dopamine neurons in rodent models of Parkinson’s disease. When administered after 6-OHDA or MPTP –lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta
UniProt ID: Q49AH0
Alternative Names: ARMETL1
Clonality: Mouse monoclonal
Clone: 7D6
Class: IgG1
Reactivity: Human, mouse; others not tested Binds to the N-terminal part of the human CDNF (aa 25-125)
Application: ELISA, WB, IF
Protocol: ELISA (rhCDNF) 0.1 to 0.2 µg/ml; ELISA (rmCDNF) 0.13 to 0.4 µg/ml; WB 0.25 to 1 µg/ml; IF 0.33 to 10 µg/ml;
Monoclonal antibody working dilution has to be established practically for each particular antigen and assay format
Purification: Protein G purification
Buffer: PBS pH 7.4, with 0.1% sodium azide
Shipping: This product is shipped in non-frozen liquid form in ambient conditions
Storage: Store at -20 °C to -70 °C upon receipt. Divide antibody into aliquots prior usage. Avoid multiple freeze-thaw cycles as product degradation may result
Research Use Only