4E-BP1 Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: RA10703-50, RA10703-100
Citations, Manuals and MSDS Available upon request.
Condition: Purified antibody in PBS containing 0.03% sodium azide.
Store at: -20°C/1 year
Recommended Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification Technology: Affinity purification
Alternative Names: EIF4EBP1, Eukaryotic translation initiation factor 4E-binding protein 1, 4E-BP1, eIF4E-binding protein 1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, PHAS-I
Background: eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1) Homo sapiens This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5&apos, end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008],
Applications: WB, IHC-p, IF (paraffin section), ELISA
Species Cross-Reactivity: Human
GeneID (Human): 1978
SWISS: Q13541
Source: Mouse
Immunogen: Purified recombinant fragment of 4E-BP1 expressed in E. Coli.
Category: Monoclonal
Research Use Only