ABflo® 450 Mouse anti-Human CD56 Monoclonal Antibody
Sizes: 100T, 2 x 100T, 5 x 100T
Catalogue Numbers: A26642-100, A26642-200, A26642-500
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein plays a role in the development of the nervous system by regulating neurogenesis, neurite outgrowth, and cell migration. This protein is also involved in the expansion of T lymphocytes, B lymphocytes and natural killer (NK) cells which play an important role in immune surveillance. This protein plays a role in signal transduction by interacting with fibroblast growth factor receptors, N-cadherin and other components of the extracellular matrix and by triggering signalling cascades involving FYN-focal adhesion kinase (FAK), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K). One prominent isoform of this gene, cell surface molecule CD56, plays a role in several myeloproliferative disorders such as acute myeloid leukemia and differential expression of this gene is associated with differential disease progression. For example, increased expression of CD56 is correlated with lower survival in acute myeloid leukemia patients whereas increased severity of COVID-19 is correlated with decreased abundance of CD56-expressing NK cells in peripheral blood. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms.
Category: Monoclonal Antibodies
Application: FC
Cross Reactivity: Human
Protein Weight: 40kDa/73kDa/80kDa/83kDa/93kDa/95kDa Immunogen: Recombinant protein (or fragment).
Species: Human
GeneID: 4684
SWISS: P13591
Alternate Names: CD56; NCAM; MSK39
Source: Mouse
Isotype: IgG1
Purity: Affinity purification
Storage: Store at 2-8℃. Avoid freeze.|Buffer: PBS with 0.09% Sodium azide,0.2% BSA,pH7.3.
Recommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume
Research Areas: Immunology Inflammation, CDs, Neuroscience, Cell Type Marker, Neurodegenerative Diseases, Stem Cells
NCBI Alias: NCAM1
Modifications: Unmodified
Conjugate: ABflo® 450. Ex:406nm. Em:445nm.
Clone Number Info: AMC0687
Research Use Only