ABflo® 450 Rabbit anti-Human PD-L1/CD274 Monoclonal Antibody
Sizes: 100T, 2 x 100T, 5 x 100T
Catalogue Numbers: A25880-100, A25880-200, A25880-500
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
Category: Monoclonal Antibodies
Application: FC
Cross Reactivity: Human
Protein Weight: 33kDa Immunogen: Recombinant protein (or fragment).
Species: Human
GeneID: 29126
SWISS: Q9NZQ7
Alternate Names: B7-H; B7H1; PDL1; PD-L1; hPD-L1; PDCD1L1; PDCD1LG1
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at 2-8℃. Avoid freeze.|Buffer: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume
Research Areas: Immunology Inflammation, CDs
NCBI Alias: CD274
Modifications: Unmodified
Conjugate: ABflo® 450. Ex:406nm. Em:445nm.
Clone Number Info: ARC5128-01
Research Use Only