ABflo® 488 Rabbit anti-Human CD206/MMR Monoclonal Antibody
Sizes: 100T, 2 x 100T, 5 x 100T
Catalogue Numbers: A28285-100, A28285-200, A28285-500
Citations, Manuals and MSDS Available upon request.
Background: The mannose receptor (MR/CLEC13D/CD206/MMR/MRC1/Macrophage Mannose Receptor 1) is an endocytic receptor expressed on dendritic cells, macrophages, and avascular endothelium. It is a highly glycosylated type I transmembrane protein featuring three distinct types of extracellular domains and a short carboxyl-terminal cytoplasmic tail that lacks obvious signaling motifs. The extracellular portion of the protein comprises an N-terminal cysteine-rich (CR) domain that binds sulfated sugar chains, a single fibronectin type II (FNII) domain that binds collagen, and eight C-type lectin domains (CTLDs) that recognize carbohydrate ligands containing mannose, fucose, and N-acetylglucosamine (GlcNAc). The receptor continuously cycles between the plasma membrane and early endosomes. Its functions include mediating antigen cross-presentation, facilitating the clearance of endogenous glycoproteins (e.g., maintaining glycoprotein homeostasis), and detecting and transporting pathogens via the lymphatics. The mannose receptor is a canonical marker for M2 macrophages.
Category: Monoclonal Antibodies
Application: FC
Cross Reactivity: Human
Protein Weight: 166kDa Immunogen: Recombinant protein (or fragment).
Species: Human
GeneID: 4360
SWISS: P22897
Alternate Names: MMR; hMR; CD206; MRC1L1; CLEC13D; CLEC13DL; bA541I19.1
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at 2-8℃. Avoid freeze.|Buffer: PBS with 0.09% Sodium azide,0.2% BSA,pH7.3.
Recommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume
Research Areas: Immunology Inflammation, CDs
NCBI Alias: MRC1
Modifications: Unmodified
Conjugate: ABflo® 488. Ex:491nm. Em:516nm.
Clone Number Info: ARC70412
Research Use Only