ABflo® 488 Rabbit anti-Human IL-1β Monoclonal Antibody
Sizes: 100T, 2 x 100T, 5 x 100T
Catalogue Numbers: A24244-100, A24244-200, A24244-500
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Category: Monoclonal Antibodies
Application: FC (intra)
Cross Reactivity: Human
Protein Weight: 30kDa Immunogen: Recombinant protein (or fragment).
Species: Human
GeneID: 3553
SWISS: P01584
Alternate Names: IL1B; IL-1; IL1-BETA; IL1F2; interleukin-1 beta
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at 2-8℃. Avoid freeze.|Buffer: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilution: FC (intra),5 μl per 10^6 cells in 100 μl volume
Research Areas: Cell Biology and Developmental Biology, Apoptosis, Growth factor, Endocrine and Metabolism, Endocrine and metabolic diseases, Obesity, Immunology and Inflammation, Cytokines, Interleukins, NF-kB Signaling Pathway, Cell Intrinsic Innate Immunity Signaling Pathway, Neuroscience, Neurodegenerative Diseases, Cardiovascular
NCBI Alias: IL1B
Modifications: Unmodified
Conjugate: ABflo® 488. Ex:491nm. Em:516nm.
Clone Number Info: ARC53391
Research Use Only