ABflo® 488 Rabbit anti-Human JAM-A/CD321/F11R Monoclonal Antibody
Sizes: 100T, 2 x 100T, 5 x 100T
Catalogue Numbers: A22592-100, A22592-200, A22592-500
Citations, Manuals and MSDS Available upon request.
Background: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.
Category: Monoclonal Antibodies
Application: FC
Cross Reactivity: Human
Protein Weight: 27kDa/32kDa Immunogen: Recombinant protein (or fragment).
Species: Human
GeneID: 50848
SWISS: Q9Y624
Alternate Names: JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at 2-8℃. Avoid freeze.|Buffer: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Cell Adhesion, Tight Junctions, Cytoskeleton, Immunology Inflammation, CDs, Cardiovascular, Blood
NCBI Alias: F11R
Modifications: Unmodified
Conjugate: ABflo® 488. Ex:491nm. Em:516nm.
Clone Number Info: ARC53966
Research Use Only