ABflo® 488 Rabbit anti-Mouse CD274/PD-L1 Monoclonal Antibody
Sizes: 100T, 2 x 100T, 5 x 100T
Catalogue Numbers: A24568-100, A24568-200, A24568-500
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis.
Category: Monoclonal Antibodies
Application: FC
Cross Reactivity: Mouse
Protein Weight: 32kDa Immunogen: Recombinant protein (or fragment).
Species: Mouse
GeneID: 60533
SWISS: Q9EP73
Alternate Names: B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at 2-8℃. Avoid freeze.|Buffer: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume
Research Areas: Immunology, Cell Type Markers, CD, Non-lineage, Immunology, Immune System Diseases, Autoimmune, Cancer, Tumor immunology, Tumor-associated antigens, Cancer, Tumor biomarkers, Tumor antigens, Signal Transduction, Antibodies, pd-l1
NCBI Alias: Cd274
Modifications: Unmodified
Conjugate: ABflo® 488. Ex:491nm. Em:516nm.
Clone Number Info: ARC61951
Research Use Only