ABflo® 594 Rabbit anti-Human CD172a/SIRPα Monoclonal Antibody
Sizes: 100T, 2 x 100T, 5 x 100T
Catalogue Numbers: A24178-100, A24178-200, A24178-500
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.
Category: Monoclonal Antibodies
Application: FC
Cross Reactivity: Human
Protein Weight: 55kDa Immunogen: Recombinant protein (or fragment).
Species: Human
GeneID: 140885
SWISS: P78324
Alternate Names: BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at 2-8℃. Avoid freeze.|Buffer: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume
Research Areas: Cell Adhesion, Immunology Inflammation, CDs, Neuroscience, Cell Type Marker, Cardiovascular, Neuron marker, Synapse marker
NCBI Alias: SIRPA
Modifications: Unmodified
Conjugate: ABflo® 594. Ex:588nm. Em:604nm.
Clone Number Info: ARC55236
Research Use Only