ABflo® 594 Rabbit anti-Human CD46 Monoclonal Antibody
Sizes: 100T, 2 x 100T, 5 x 100T
Catalogue Numbers: A25552-100, A25552-200, A25552-500
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
Category: Monoclonal Antibodies
Application: FC
Cross Reactivity: Human
Protein Weight: 37-44kDa Immunogen: Recombinant protein (or fragment).
Species: Human
GeneID: 4179
SWISS: P15529
Alternate Names: MCP; TLX; AHUS2; MIC10; TRA2.10
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at 2-8℃. Avoid freeze.|Buffer: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume
Research Areas: Immunology Inflammation, CDs, Cell Intrinsic Innate Immunity Signaling Pathway
NCBI Alias: CD46
Modifications: Unmodified
Conjugate: ABflo® 594. Ex:588nm. Em:604nm.
Clone Number Info: ARC65046
Research Use Only