ABflo® 647 Rabbit anti-Human FGFR3 Monoclonal Antibody
Sizes: 100T, 2 x 100T, 5 x 100T
Catalogue Numbers: A27213-100, A27213-200, A27213-500
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.
Category: Monoclonal Antibodies
Application: FC
Cross Reactivity: Human
Protein Weight: 88kDa Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 23-375 of human FGFR3 (NP_000133.1).
Species: Human
GeneID: 2261
SWISS: P22607
Alternate Names: ACH; CEK2; JTK4; CD333; HSFGFR3EX
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at 2-8℃. Avoid freeze.|Buffer: PBS with 0.09% Sodium azide,0.2% BSA,pH7.3.
Recommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume
Research Areas: Cancer, Signal Transduction, Kinase, Tyrosine kinases, Cell Biology Developmental Biology, Growth factors, ESC Pluripotency and Differentiation, Immunology Inflammation, CDs, Stem Cells, Neural Stem Cells, Cardiovascular, Angiogenesis
NCBI Alias: FGFR3
Modifications: Unmodified
Conjugate: ABflo® 647. Ex:648nm. Em:664nm.
Clone Number Info: ARC67636
Research Use Only