APC Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: MB11920-50, MB11920-100
Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Swiss-Prot: P25054
Host: Rabbit
Reactivity: Human
Applications: WB, ICC/IF, IP,
All Applications: WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20
Background: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
Purification and Purity: Affinity Purified
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: IgG
Bioworld Molecular Weight: Calculated MW: 312 kDa; Observed MW: 160 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Immunocytochemistry analysis of APC in LNcap using APC antibody, and DAPI., Western blot analysis of APC in Hela, A549, HL-60, U2OS lysates using APC antibody.
Alternative Name: APC; DP2.5; Adenomatous polyposis coli protein; Protein APC; Deleted in polyposis 2.5
Immunogen: A synthetic peptide of human APC
Conjugate: Unconjugated
Modification: Unmodified