APCS Monoclonal Antibody
Catalogue Numbers: MB66780-50, MB66780-100
Sizes: 50µl, 100µl
Product: Mouse IgG2a. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Swiss-Prot: P02743
Host: Mouse
Reactivity: Human
Applications: WB
All Applications: WB (1/500 - 1/1000)
Background: Serum amyloid P (SAP) is a glycoprotein belonging to the pentraxin family of proteins, which has a characteristic pentameric organization and calciumdependent ligand binding. Secreted by liver epithelial cells, SAP is found in serum and urine. Although the function of SAP has not been clearly established, it has been shown to interact with DNA and histones and is thought to play a role in scavenging nuclear material released from damaged circulating cells. Also designated PTX2, SAP is a precursor of the protein amyloid P component (AP), which is universally associated with the amyloid deposits in all forms of amyloidoses, including Alzheimer’s disease. SAP is a decamer of ten identical, noncovalently linked subunits, each of which may be posttranslationally modified by glycosylation.
Purification and Purity: This antibody is purified through a protein G column.
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Recognizes endogenous levels of APCS protein.
Extra Notes: Western blot analysis of APCS expression in NCIH460 (A) whole cell lysates.
Bioworld Molecular Weight: ~ 28 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Name: PTX2; Serum amyloid P-component; SAP; 9.5S alpha-1-glycoprotein
Immunogen: Recombinant fusion protein of human APCS. The exact sequence is proprietary.
Conjugate: Unconjugated
Modification: Unmodified