Apolipoprotein A1/APOA1 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A24291-20, A24291-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein.
Synonyms: HPALP2; apo(a); Apolipoprotein A1/APOA1
GeneID: 335
Swiss-Prot: P02647
Reactivity: Human, Mouse
Tested Applications: ELISA, WB, IF/ICC, IP
Calculated Molecular Weight: 28kDa
Observed Molecular Weight: 28kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-267 of human Apolipoprotein A1/APOA1 (NP_000030.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Cancer, Signal Transduction, Endocrine Metabolism, Lipid Metabolism, Neuroscience, Neurodegenerative Diseases, Cardiovascular, Heart, Lipids, Cardiovascular diseases, Heart disease
Recommended Dilutions: WB: 1:1000 - 1:5000 | IF/ICC: 1:50 - 1:200 | IP: 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Blood microparticle, Cytoplasmic Vesicle, Cytosol, Early Endosome, Endoplasmic Reticulum Lumen, Extra Cellular Exosome, Extra Cellular Region, Extra Cellular Space, Extra Cellular Vesicle, Plasma Membrane,
Positive Samples: Hep G2, Mouse plasma
Keywords: APOA1, apo(a), apolipoprotein A1, apolipoprotein A-I|apo-AI, P02647, Apolipoprotein A1/APOA1
Symbol: APOA1
Category: Monoclonal Antibodies
Research Use Only