APPBP1 Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: MB10559-50, MB10559-100
Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Swiss-Prot: Q13564
Host: Rabbit
Reactivity: Human
Applications: WB,IP
All Applications: WB: 1/500-1/1000 IP: 1/20
Background: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
Purification and Purity: Affinity Purified
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of APPBP1 in SKOV-3Lysates using APPBP1 antibody.
Bioworld Molecular Weight: Calculated MW: 60 kDa; Observed MW: 60 kDa
Specificity: IgG
Alternative Name: NEDD8 activating enzyme E1 subunit 1; HPP1; ula-1; APPBP1; A-116A10.1
Immunogen: A synthetic peptide of human APPBP1
Conjugate: Unconjugated
Modification: Unmodified