c-Abl Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A22082-20, A22082-100
Citations, Manuals and SDS Available upon request.
Background: This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.
Synonyms: ABL; JTK7; p150; c-ABL; v-abl; CHDSKM; c-ABL1; BCR-ABL; bcr/abl; c-Abl
GeneID: 25
Swiss-Prot: P00519
Reactivity: Human
Tested Applications: ELISA, WB
Calculated Molecular Weight: 123kDa
Observed Molecular Weight: 140kDa/210kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1000-1130 of human c-Abl (NP_005148.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Epigenetics Nuclear Signaling, Protein phosphorylation, Cancer, Signal Transduction, Kinase, Tyrosine kinases, ErbB-HER Signaling Pathway, MAPK-JNK Signaling Pathway, ATM Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Cell Cycle, Cell Cycle Control-G1 S Checkpoint, Cell Cycle Control-G2 M DNA Damage Checkpoint, Microtubules, TGF-b-Smad Signaling Pathway, Immunology Inflammation
Recommended Dilutions: WB: 1:1000 - 1:5000
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cytoplasm, Lipid-anchor, Mitochondrion, Nucleus, Nucleus Membrane, Cytoskeleton
Positive Samples: 293F
Keywords: 25, sc-13076, sc-887, sc-131, ABL1, ABL, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl, ABL proto-oncogene 1, non-receptor tyrosine kinase, tyrosine-protein kinase ABL1, Abelson tyrosine-protein kinase 1, bcr/c-abl oncogene protein, c-abl oncogene 1, receptor tyrosine kinase, proto-oncogene c-Abl, proto-oncogene tyrosine-protein kinase ABL1, v-abl Abelson murine leukemia viral oncogene homolog 1, P00519, ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase, V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 1, C-Abl Oncogene 1, Receptor Tyrosine Kinase, Abelson Tyrosine-Protein Kinase 1, Proto-Oncogene C-Abl, P150, Abelson Murine Leukemia Viral Oncogene Homolog 1, Proto-Oncogene Tyrosine-Protein Kinase ABL1, Tyrosine-Protein Kinase ABL1, Bcr/C-Abl Oncogene Protein, EC 2.7.10.2, Bcr/Abl, CHDSKM, C-ABL1, C-ABL, V-Abl, c-Abl, cABL, c ABL, vabl, v abl, cABL1, c ABL1, sc13076, sc 13076, sc887, sc 887, sc131, sc 131
Symbol: ABL1
Category: Monoclonal Antibodies
Research Use Only