CA125 / MUC16 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A4666-20, A4666-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes.
Synonyms: CA125; CA-125 ; CA125 / MUC16
GeneID: 94025
Swiss-Prot: Q8WXI7
Reactivity: Human
Calculated Molecular Weight: 1519kDa
Observed Molecular Weight: 270kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 12200-12300 of human CA125 / MUC16 (NP_078966.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000
Research Areas: Cancer, Invasion and Metastasis, Cell Biology Developmental Biology, Cytoskeleton, Extracellular Matrix
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: OVCAR3
Cellular Location: Extra Cellular Exosome, Golgi Lumen, Plasma Membrane
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.