Calumenin (C-terminus) Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: MB0120-50, MB0120-100
Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: O43852
Host: Mouse IgG1
Reactivity: Human, Mouse
Applications: WB
All Applications: WB:1:1000
Background: Caluminin is a 315 amino acid Ca2+-binding member of the CREC, EF-hand protein family. Calumenin is a secreted protein t hat contains six Ca2+-binding (EF-hand) motifs and is expressed in the lumen of the endoplasmic reticulum (ER) and Golgi apparatus. In the presence of Ca2+, Calumenin interacts with serum amyloid P component (SAP) and, together, they may play a role in the immunological defense system and participate in amyloidosis, the pathological formation of amyloid deposits in different types of tissues. Calumenin has an inhibitory effect on the vitamin K-dependent g-carboxylation system which converts vitamin K-dependent proteins to Gla-containing proteins. Calumenin may also be involved in the pathophysiology of thrombosis and/or wound healing by acting in an autocrine or paracrine manner.
Purification and Purity: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Calumenin (C-terminus) mAb detects endogenous levels of Calumenin protein.
Bioworld Molecular Weight: Predicted band size:37KDa
Observed band size:45KDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western BlotDetection of CALU in SW480, mouse intestine &A431 cell lysates and using CALU antibody (1:1000 diluted).
Alternative Name: Crocalbin; IEF SSP 9302; CALU
Immunogen: Synthetic peptide, corresponding to amino acids C-terminus of Human Calumenin.
Conjugate: Unconjugated
Modification: Unmodified