CaMKK beta Monoclonal Antibody
Catalogue Numbers: MB67180-50, MB67180-100
Sizes: 50µl, 100µl
Product: Mouse IgM kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Swiss-Prot: Q96RR4
Host: Mouse
Reactivity: Human, Mouse
Applications: WB
All Applications: WB (1/500 - 1/1000)
Background: Calcium/Calmodulin-dependent Protein Kinase Kinase 2 (CaMKK2) is a member of the CaMK family that contains a central Ser/Thr kinase domain followed by a regulatory domain consisting of overlapping autoinhibitory and CaM-binding regions. CaMKK2 can be distinguished from other CaMK family members by the presence of a unique Pro/Arg/Gly-rich insert following the ATP-binding domain. CaMKK2 phosphorylates CaMKI at Thr177 and CaMKIV at Thr200. CaMKK2 also phosphorylates AMPKα in response to calcium. CaMKK2 has been implicated in long-term memory formation and adipocyte development. CaMKK2 is phosphorylated at Ser511 by death-associated protein kinase (DAPK) in a signaling cascade thought to be involved in neuronal death.
Purification and Purity: This antibody is purified through a protein G column.
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Recognizes endogenous levels of CaMKK beta protein.
Extra Notes: Western blot analysis of CaMKK beta expression in NCIH1299 (A) whole cell lysates.
Bioworld Molecular Weight: ~ 70 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Name: CAMKKB; KIAA0787; Calcium/calmodulin-dependent protein kinase kinase 2; CaM-KK 2; CaM-kinase kinase 2; CaMKK 2; Calcium/calmodulin-dependent protein kinase kinase beta; CaM-KK beta; CaM-kinase kinase beta; CaMKK beta
Immunogen: Recombinant fusion protein of human CaMKK beta. The exact sequence is proprietary.
Conjugate: Unconjugated
Modification: Unmodified