Caspase 11 Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: MB10660-50, MB10660-100
Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Swiss-Prot: P70343
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB,IP
All Applications: WB: 1/500-1/1000 IP: 1/20
Background: Proinflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS, as well as infection with Gram-negative bacteria. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators.
Purification and Purity: Affinity Purified
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of Caspase11 in C6, 3T3, HelaLysates using Caspase 11 antibody.
Bioworld Molecular Weight: Calculated MW: 43 kDa; Observed MW: 43,38,25 kDa
Specificity: IgG
Alternative Name: Caspl; ich-3; CASP-4; Casp11; CASP-11
Immunogen: Recombinant protein of mouse Caspase-11
Conjugate: Unconjugated
Modification: Unmodified