Caspase-12 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A22864-20, A22864-100
Citations, Manuals and SDS Available upon request.
Background: Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.
Synonyms: CASP-12; CASP12P1; Caspase-12
GeneID: 100506742
Swiss-Prot: Q6UXS9
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB, IHC-P, IF/ICC
Calculated Molecular Weight: 39kDa
Observed Molecular Weight: 55kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Caspase-12(NP_001177945.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Cancer, Invasion and Metastasis, Apoptosis, Caspases, Ubiquitin, Endocrine Metabolism, Neuroscience, Neurodegenerative Diseases, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease
Recommended Dilutions: WB: 1:500 - 1:1000 | IHC-P: 1:500 - 1:1000 | IF/ICC: 1:50 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: AIM2 inflammasome Complex, Cytoplasm, Endoplasmic Reticulum, IPAF inflammasome Complex, NLRP3 inflammasome Complex,
Positive Samples: Mouse liver, Rat liver
Keywords: 100506742, CASP12, CASP-12, CASP12P1, caspase 12 (gene/pseudogene), inactive caspase-12, caspase 12 pseudogene 1, Q6UXS9, Caspase 12 (Gene/Pseudogene), Caspase 12 Pseudogene 1, Inactive Caspase-12, Caspase 12, Caspase-12, CASP 12
Symbol: CASP12
Category: Monoclonal Antibodies
Research Use Only