Caspase-3 Mouse Monoclonal Antibody (4B8)
Sizes: 50μL, 100μL
Catalogue Number: RA10891-50, RA10891-100
Citations, Manuals and MSDS Available upon request.
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Store At/In: -20°C/1 year
Recommended Dilutions: IHC 1:100-200
Alternative Names: CASP3
Background: caspase 3(CASP3) Homo sapiens This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008],
Applications: IHC-p; IF(paraffin section)
Species Cross-Reactivity: Human; Rat; Mouse
Molecular Weight: 17、32
GeneID (Human): 836
Protein MW (KDa): 17、32
SWISS: P42574
Source: Mouse
Research Use Only