Caspase 8 Rabbit Monoclonal Antibody
Catalogue Numbers: MB66324-50, MB66324-100
Sizes: 50µl, 100µl
Product: Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.
Swiss-Prot: O89110
Host: Rabbit
Reactivity: Hamster
Applications: WB
All Applications: WB (1/500 - 1/1000)
Background: Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10. Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage.
Purification and Purity: The antibody was purified by immunogen affinity chromatography.
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Recognizes endogenous levels of Caspase 8 protein.
Extra Notes: Western blot analysis of Caspase 8 expression in CHOK1 (A) whole cell lysates.
Bioworld Molecular Weight: ~ 55 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Name: MCH5; Caspase-8; CASP-8; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; MACH
Immunogen: A synthetic peptide of human Caspase-8
Conjugate: Unconjugated
Modification: Unmodified